Hi ya,
Your question is so broad that it would be almost impossible to answer
If you mean "what do I need to know in order to code games using the isogenic engine" then the answer is:
* Good knowledge and understanding of JavaScript
* Experience with debugging web-based applications using browser-based console and programmer dev tools (e.g. Chrome Dev Tools)
* Understanding of http and how the web works is a bonus.
If you are looking to create a multiplayer game you will also need to understand:
* Realtime networking concepts like latency, bandwidth, packets, data encoding, transports.
* Server-side JavaScript programming using Node.js
* Experience writing single-player (or "offline") games in JavaScript - if you have never done this, don't even try to make a multiplayer game unless you are doing it as an experiment and to learn rather than for production.
Even with an engine, writing a computer game from start to finish is one of the most complex and difficult programming tasks any programmer can take on. You should be confident in your language (JavaScript) and your tools before you begin.